The Truman saw continuous action for over 50 days, conducting precision airstrikes and launching missiles while under constant fire from Houthi militants.
Sixteen aircraft dropped 124,000 pounds of ordnance in less than two minutes during a Feb. 1 airstrike in Somalia, a defense official told Military Times.
The incident, in which the pilots were safely recovered, marks the third time since December that an F/A-18 assigned to the carrier Truman has been lost.